Vet World Vol.17 July-2024 Article - 4
Research Article
Veterinary World, 17(7): 1449-1458
https://doi.org/10.14202/vetworld.2024.1449-1458
Assessment of oral toxicity of Moringa oleifera Lam aqueous extract and its effect on gout induced in a murine model
2. Section of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
3. Section of Physiology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Background and Aim: Although widely employed in traditional remedies globally, the safety and efficacy of Moringa oleifera remain inadequately documented through scientific research. This study evaluated the oral toxicity of M. oleifera leaf aqueous extract (MoAE) and its impact on gout-induced rats.
Materials and Methods: 2000 mg/kg was given in a single dose during the acute oral toxicity test, while 100 mg/kg, 250 mg/kg, and 500 mg/kg were given daily for 28 days in the repeated dose toxicity test. 100 mg/kg, 250 mg/kg, and 500 mg/kg MoAE doses were administered during the assessment of its impact on gout caused by monosodium urate. In the hyperuricemia model induced by oxonic acid, serum uric acid levels were assessed and pain response was measured through acetic acid-induced writhing.
Results: In acute oral and 28-day repeated dose tests, no indications of toxicity were detected, while MoAE alleviated ankle joint swelling and reduced serum uric acid concentrations in arthritic rats, causing a significant reduction in acetic acid-induced contortions.
Conclusion: No acute oral toxicity or toxicity in 28-day repeated doses was found for MoAE, while it exhibited antiarthritic, antihyperuricemic, and pain-relieving effects in the murine model.
Keywords: extract, gout, Moringa oleifera, murine, toxicity.
How to cite this article: Palomino-Pacheco M, Rojas-Armas JP, Ortiz-Sánchez JM, Arroyo-Acevedo JL, Justil-Guerrero HJ, and Martínez-Heredia JT (2024) Assessment of oral toxicity of Moringa oleifera Lam aqueous extract and its effect on gout induced in a murine model, Veterinary World, 17(7): 1449–1458.
Received: 2024-04-05 Accepted: 2024-06-07 Published online: 2024-07-07
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.1449-1458
Copyright: Palomino-Pacheco, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
